Publications

Deep Network Pharmacology: Targeting Glutamate Systems as Integrative Treatments for Jump-Starting Neural Networks and Recovery Trajectories – PubMed (nih.gov)

Chambers RA, Toombs C:   Deep Network Pharmacology: Targeting Glutamate Systems as Integrative Treatments for Jump-Starting Neural Networks and Recovery Trajectories. J Psychiatry Brain Sci. 2021;6:e210008.

The neural basis of addiction: a pathology of motivation and choice – PubMed (nih.gov)

Kalivas PW, Volkow ND. The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry. 2005 Aug;162(8):1403-13. doi: 10.1176/appi.ajp.162.8.1403. PMID: 16055761.

Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters – PubMed (nih.gov)

Niedzielska-Andres E, Pomierny-Chamioło L, Andres M, Walczak M, Knackstedt LA, Filip M, Przegaliński E. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacol Ther. 2021 May;221:107797. doi: 10.1016/j.pharmthera.2020.107797. Epub 2021 Jan 9. PMID: 33359590.

NIDA’s medication development priorities in response to the Opioid Crisis: ten most wanted – PubMed (nih.gov)

Rasmussen K, White DA, Acri JB. NIDA’s medication development priorities in response to the Opioid Crisis: ten most wanted. Neuropsychopharmacology. 2019 Mar;44(4):657-659. doi: 10.1038/s41386-018-0292-5. Epub 2018 Dec 7. PMID: 30538289; PMCID: PMC6372702.

A selective AMPA antagonist, LY293558, suppresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal – PubMed (nih.gov)

Rasmussen K, Kendrick WT, Kogan JH, Aghajanian GK. A selective AMPA antagonist, LY293558, suppresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropsychopharmacology. 1996 Nov;15(5):497-505. doi: 10.1016/S0893-133X(96)00094-2. PMID: 8914123.

AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans – PubMed (nih.gov)

Sang CN, Hostetter MP, Gracely RH, Chappell AS, Schoepp DD, Lee G, Whitcup S, Caruso R, Max MB. AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans. Anesthesiology. 1998 Nov;89(5):1060-7. doi: 10.1097/00000542-199811000-00005. PMID: 9821993.

LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine – PubMed (nih.gov)

Sang CN, Ramadan NM, Wallihan RG, Chappell AS, Freitag FG, Smith TR, Silberstein SD, Johnson KW, Phebus LA, Bleakman D, Ornstein PL, Arnold B, Tepper SJ, Vandenhende F. LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine. Cephalalgia. 2004 Jul;24(7):596-602. doi: 10.1111/j.1468-2982.2004.00723.x. PMID: 15196302.